Melanotan I (MT1) – Research Grade Peptide

Melanotan I, also known as Afamelanotide or NDP-MSH, is a synthetic analog of alpha-MSH (melanocyte-stimulating hormone) developed for its powerful melanogenesis-stimulating effects. It is primarily studied in research focused on skin pigmentation, UV protection, and melanocortin receptor activity, particularly MC1R.

Unlike Melanotan II (MT2), Melanotan I does not affect libido or appetite, making it ideal for selective studies on skin pigmentation and photoprotection. In models, MT1 has demonstrated potent sunless tanning potential, antioxidant activity, and reduced phototoxicity.

⚙️ Key Features

• ✅ High-purity 10mg research vial

• ✅ ≥98% purity (HPLC-verified)

• ✅ Selective MC1R agonist

• ✅ Does not affect sexual or appetite pathways

• ✅ Non-liposomal, stable lyophilized format

• ✅ Manufactured in GMP-compliant facilities

📚 Mechanism of Action

Melanotan I works by stimulating the melanocortin 1 receptor (MC1R), a critical component in the production of melanin. Activation of MC1R enhances eumelanin synthesis, which darkens the skin and increases resistance to UV radiation.

This peptide is structurally stable, shows longer half-life compared to natural alpha-MSH, and is resistant to enzymatic degradation, making it highly suitable for long-term pigmentation studies.

🔬 Research Applications

🌞 Skin Pigmentation & UV Protection
Studied for inducing a natural tan-like response without sun exposure, potentially reducing the risk of sunburn or UV-induced skin damage.

🧬 Melanocortin Receptor Activation
Used in research involving MC1R receptor signaling, melanogenesis, and pigment cell biology.

🧪 Photodermatosis & Light-Sensitive Conditions
Explored in preclinical models of erythropoietic protoporphyria (EPP) and other light-intolerance disorders.

💡 Oxidative Stress & Antioxidant Response
Shown in some models to enhance cellular defense against oxidative stress and UV-induced damage.

🧪 Reconstitution & Storage Instructions

• Diluent: Bacteriostatic Water (BAC)

• Suggested Volume: 2–3mL BAC per 10mg vial

• Storage (Lyophilized): -20°C in light-proof container

• Storage (Reconstituted): 2–8°C; use within 30 days

• Do not freeze after reconstitution

• Protect from light and humidity

📦 What’s Included

• 1 Vial of Melanotan I (MT1) – 10mg

• Certificate of Analysis (CoA)

• Tamper-evident seal and batch verification

• Cold-chain shipping available (optional)

🚫 Disclaimer

Melanotan I is sold strictly for laboratory research purposes only. It is not intended for human consumption, therapeutic use, or cosmetic application. Purchase and handling restricted to qualified institutions and researchers.