Semaglutide

Semaglutide is a synthetic GLP-1 (glucagon-like peptide-1) receptor agonist, widely studied in research related to type 2 diabetes, obesity, weight regulation, insulin sensitivity, and appetite suppression. It is structurally modified to resist DPP-4 degradation and has a long half-life, making it ideal for extended physiological studies.

ChemDope offers Semaglutide in both 5mg and 10mg lyophilized vials, allowing flexibility for small-scale or extended experiments.

⚙️ Key Features

• ✅ High-purity 5mg or 10mg lyophilized Semaglutide

• ✅ Manufactured in GMP-certified facilities

• ✅ ≥98% purity validated by HPLC

• ✅ Stable and potent GLP-1 analog

• ✅ Ideal for metabolic, diabetes, and appetite studies

• ✅ Comes with Certificate of Analysis (CoA)

📚 Mechanism of Action

Semaglutide mimics native GLP-1, a hormone that plays a vital role in glucose homeostasis and appetite regulation. It binds to the GLP-1 receptor, enhancing glucose-dependent insulin secretion, reducing glucagon release, and delaying gastric emptying.

Its long half-life enables once-weekly dosing models in research, enhancing consistency in chronic metabolic studies.

🔬 Research Applications

⚖️ Obesity & Weight Management Studies
Semaglutide is extensively studied for its effects on body weight, satiety, and caloric intake regulation.

🩺 Type 2 Diabetes Research
Promotes insulin sensitivity, glucose control, and HbA1c reduction in diabetic models.

🧠 Appetite & Behavior Regulation
Explored in neuroendocrine pathways for controlling hunger signaling and cravings.

🧪 Metabolic Syndrome Models
Used in evaluating lipid profiles, insulin response, and energy expenditure.

🧪 Reconstitution & Storage Instructions

• Suggested Diluent: Bacteriostatic Water (BAC)

• Volume to Reconstitute: 1–2mL per vial (based on concentration needs)

• Lyophilized Storage: -20°C in dry, light-protected conditions

• After Reconstitution: Store at 2–8°C for up to 30 days

• Do not freeze after reconstitution

• Use only under sterile lab conditions

📦 What’s Included

• 1 Vial of Semaglutide 5mg or 10mg (lyophilized)

• Certificate of Analysis (CoA)

• Tamper-proof packaging

• Batch-specific documentation

• Cold-chain shipping available

🚫 Disclaimer

Semaglutide is strictly for laboratory research use only. Not for human consumption, therapeutic, or diagnostic use. Only licensed researchers and institutions may handle this compound.