PNC-27 Peptide 5mg & 10mg (Research Grade)

PNC-27 Peptide 5mg & 10mg – High Purity Cancer Research Peptide

PNC-27 is a revolutionary synthetic peptide designed for advanced cancer research, particularly in studies involving tumor suppression, targeted cancer cell apoptosis, and HDM-2 pathway interference. As a p53-mimetic peptide, PNC-27 has shown promising selective cytotoxicity toward cancer cells in preclinical models, making it a valuable compound for researchers exploring novel anticancer therapeutics.

Available in 5mg and 10mg lyophilized vials, PNC-27 is formulated for stability, purity, and consistent performance in in vitro and in vivo laboratory settings. It is intended strictly for research use and not approved for clinical or diagnostic applications.

What is PNC-27?

PNC-27 is a peptide engineered from a modified sequence of the p53 tumor suppressor protein, fused with a membrane-penetrating sequence to ensure effective cellular entry. The key functional domain of p53 that binds to the MDM2 (or HDM-2 in humans) protein is retained in the PNC-27 sequence. This interaction plays a crucial role in inducing cell death in cancer cells, particularly those overexpressing HDM-2.

PNC-27 contains two critical components:

• The HDM-2 binding region of the p53 protein, which is responsible for targeting HDM-2 proteins on the cancer cell surface.

• A membrane-translocating sequence (MTD), which enables the peptide to effectively penetrate the lipid bilayer and localize within the cellular membrane or cytoplasm.

This dual mechanism makes PNC-27 a subject of intense interest in oncology, molecular biology, and peptide-based therapeutic research.

Mechanism of Action

PNC-27 binds with high affinity to the HDM-2 receptors, which are frequently overexpressed on the surface of various tumor cells. Unlike traditional cancer treatments that also affect healthy tissues, PNC-27 displays selective cytotoxicity, targeting only the malignant cells.

Once bound, the peptide facilitates the formation of transmembrane pores in the cancer cell membrane, leading to:

• Membrane disruption

• Loss of cellular integrity

• Rapid apoptosis or necrosis

This makes PNC-27 an ideal candidate for researchers interested in studying targeted cancer therapy, HDM-2 inhibition, and selective cell death pathways.

Product Specifications

• Product Name: PNC-27

• Form: Lyophilized Powder

• Purity: ≥98% (HPLC Verified)

• Available Quantities: 5mg / 10mg

• Sequence: H-GGGS-NH2-KKKQGSYGLRLFTEYKKKK-NH2

• Molecular Weight: ~2610 g/mol

• Storage Conditions: Store lyophilized at -20°C; reconstituted solution stable for up to 30 days at 2–8°C

• Solubility: Soluble in sterile water, PBS, or peptide-grade solvents

• Shelf Life: 24 months (unopened and properly stored)

Applications in Research

1. Cancer Cell Targeting and Apoptosis Studies

Its activity in inducing apoptosis without harming normal cells makes it a unique model for cancer-specific drug delivery systems.

2. HDM-2 (MDM2) Pathway Inhibition

As an HDM-2 inhibitor, it allows researchers to explore how tumor cells evade apoptosis by degrading p53. Studies on HDM-2 overexpression in various cancers, including breast, colon, pancreatic, and melanoma, benefit from this peptide’s targeting mechanism.

3. Pore-Forming Peptides and Membrane Disruption Research

It is also utilized in studying how peptides can disrupt cell membranes—a mechanism relevant not only to oncology but also to antimicrobial peptide research and lipid membrane modeling.

4. Combination Therapy Research

Researchers are investigating how it can synergize with chemotherapy agents, radiation, or immune checkpoint inhibitors to enhance their selectivity and efficacy against malignant cells.

Research-Backed Benefits

• Selective targeting of cancer cells, sparing healthy tissues

• No observed toxicity in normal human cell lines (in preclinical studies)

• Induces apoptosis via membrane pore formation

• Valuable for studies on p53 tumor suppressor pathways

• Enables development of targeted drug delivery mechanisms

Product Usage & Handling

Reconstitution Instructions:
Reconstitute PNC-27 with sterile bacteriostatic water or peptide-grade solvents to a concentration appropriate for your application. Gently swirl—do not vortex—to dissolve completely.

Storage Guidelines:

• Store dry vials at -20°C

• Use reconstituted solution within 30 days if kept at 2–8°C

• Avoid repeated freeze-thaw cycles

Legal and Safety Disclaimer

For Research Use Only. Not for human consumption.
PNC-27 is not intended for diagnostic, therapeutic, or clinical use. Use only in certified laboratories by trained professionals. Mishandling or misuse may lead to safety and legal consequences. Always consult local regulations before handling research peptides.

Why Choose High-Purity PNC-27 Peptide?

• Consistency: Batch-tested for purity, identity, and stability

• Quality Control: Each vial undergoes stringent HPLC and mass spectrometry validation

• Purity Guarantee: ≥98% ensures minimal byproducts or degradation

• Flexible Sizes: Available in both 5mg and 10mg to meet small or large-scale research needs

Ideal for Researchers Involved In:

• Oncology and tumor biology

• Molecular pharmacology

• Cancer immunotherapy

• Apoptosis and cell death signaling

• HDM-2 and p53 protein interaction studies

• Peptide-based drug delivery modeling