ARA 290 Peptide

ARA 290 is a synthetic non-hematopoietic peptide derived from the B-helix of erythropoietin (EPO). It is designed to retain the cytoprotective and anti-inflammatory benefits of EPO without triggering erythropoiesis (red blood cell production), making it a valuable research compound for neuropathy, inflammation, tissue regeneration, and chronic pain.

Offered in 5mg and 10mg lyophilized powder vials, ARA 290 is manufactured at ≥98% purity, intended strictly for research use only in laboratory and preclinical environments. It is a promising peptide for studies involving small fiber neuropathy, autoimmune conditions, wound healing, and organ protection following ischemia.

Chemical & Physical Properties:

• Product Name: ARA 290

• Form: Lyophilized powder

• Purity: ≥98% (HPLC Verified)

• Dosages: 5mg / 10mg per vial

• Molecular Formula: C106H157N27O27

• Molecular Weight: ~2250.6 g/mol

• Sequence: LERPQLERALNSS

• Solubility: Soluble in sterile water or PBS

• Storage: Store at -20°C dry. Reconstituted solution stable at 2–8°C for 30 days.

What is ARA 290?

ARA 290 is a 13-amino acid synthetic peptide modeled after the tissue-protective domain of erythropoietin (EPO). Unlike full-length EPO, it is engineered to activate the innate repair receptor (IRR) — a heterodimer composed of EPOR and CD131 — without binding to the classical erythropoietin receptor responsible for red blood cell stimulation.

This selective interaction allows product to provide tissue protection, anti-inflammatory, and neuroprotective effects without raising hematocrit or inducing other side effects typically associated with recombinant EPO.

Mechanism of Action:

ARA 290 exerts its activity by binding to the innate repair receptor (IRR) rather than the classic EPO receptor. This receptor is upregulated in damaged or inflamed tissues, allowing to trigger localized repair mechanisms.

Its action includes:

• Downregulation of pro-inflammatory cytokines (e.g., TNF-α, IL-6)

• Reduction of oxidative stress and free radical damage

• Promotion of angiogenesis and tissue regeneration

• Protection against apoptosis and fibrosis

• Restoration of small nerve fiber density

Research Applications of ARA 290:

1. Neuropathy & Chronic Pain Research

ARA 290 is extensively studied in models of small fiber neuropathy, diabetic neuropathy, and sarcoidosis-related nerve damage. Research shows that it promotes nerve regeneration, reduces neuropathic pain, and restores epidermal nerve fiber density.

2. Autoimmune & Inflammatory Disease Models

Due to its strong anti-inflammatory profile, it is relevant in autoimmune disorders like lupus, sarcoidosis, and multiple sclerosis. It reduces inflammatory cell infiltration and promotes tissue tolerance.

3. Tissue Protection & Ischemia Models

ARA 290’s cytoprotective activity makes it ideal for models of ischemia-reperfusion injury, such as in kidney, liver, cardiac, or brain tissue following trauma or surgery.

4. Wound Healing & Regenerative Medicine

By modulating macrophage phenotype and promoting tissue-resident stem cell activation, It shows promise in skin regeneration, wound closure, and organ preservation studies.

Benefits of ARA 290 in Research:

• Non-erythropoietic: No increase in hematocrit or RBCs

• Promotes nerve regeneration and density

• Reduces inflammation and oxidative damage

• Enhances healing in injured tissues

• No known prothrombotic or immunogenic effects

• Ideal for chronic pain and neuropathy models

Usage & Handling Instructions:

Reconstitution Instructions:
Reconstitute ARA 290 in sterile bacteriostatic water or PBS buffer. Gently swirl the vial to mix—do not shake vigorously.

Storage Guidelines:

• Store lyophilized vials at -20°C

• After reconstitution, store at 2–8°C and use within 30 days

• Avoid multiple freeze-thaw cycles

Legal Disclaimer:

For Laboratory Research Use Only. Not for human or veterinary consumption.
It is not intended to diagnose, treat, cure, or prevent any disease. Use only in certified laboratory environments by qualified professionals.

Who Should Use ARA 290 in Research?

Ideal for researchers in the fields of:

• Neurology and Pain Science

• Inflammatory Disease Research

• Wound Healing and Tissue Repair

• Renal, Liver, and Cardiac Ischemia

• Autoimmune Disease Modeling

• Regenerative Medicine and Peptide Pharmacology

• erythropoietin-derived research peptide