Protirelin (TRH Peptide) – 5mg & 10mg

Product Name: Protirelin
Synonyms: TRH, Thyrotropin-Releasing Hormone, Thyroliberin, TRH-Tyr
CAS Number: 24305-27-9
Molecular Formula: C16H22N6O4
Molecular Weight: ~362.39 g/mol
Form: Lyophilized White Powder
Purity: ≥98% (HPLC Verified)
Sizes Available: 5mg and 10mg vials
Storage (Lyophilized): –20°C, protected from light and moisture
Storage (Reconstituted): 2–8°C for up to 30 days
Use: For laboratory research only in the United States

Product Overview

Protirelin (TRH) is a tripeptide hormone known as Thyrotropin-Releasing Hormone, a key regulator in the hypothalamic-pituitary-thyroid (HPT) axis. It stimulates the anterior pituitary to secrete thyroid-stimulating hormone (TSH) and prolactin in mammalian models.

At ChemDope.com, we provide research-grade Protirelin in 5mg and 10mg vials, manufactured in FDA-registered U.S. facilities under cGMP conditions. Each vial includes a Certificate of Analysis (CoA) and is tested for ≥98% purity by HPLC.

✅ Key Features

• High-purity TRH peptide (≥98% by HPLC)

• 5mg & 10mg sterile lyophilized vials

• Manufactured in the USA under strict cGMP conditions

• Targets thyroid regulation, neuroendocrine activity & CNS stimulation

• CoA included with batch traceability

• Fast U.S. shipping with cold-pack option available

???? Mechanism of Action

Protirelin (TRH) acts primarily on the anterior pituitary gland, binding to specific TRH receptors to stimulate:

• TSH (Thyroid Stimulating Hormone) release

• Prolactin secretion

• Central nervous system effects such as increased alertness and sympathetic tone

Due to its role in thyroid hormone regulation, Protirelin is a powerful tool for research into metabolism, neurobiology, endocrine feedback loops, and neurotransmitter modulation.

???? Research Applications

???? Endocrine System Research
Used in models to study thyroid hormone regulation, HPT axis feedback, and pituitary signaling.

???? Neuroendocrinology Studies
Explores TRH’s role in arousal, mood, and neuropeptide release.

???? Prolactin Regulation Research
Applied in studies examining dopamine-prolactin interaction and hypothalamic function.

???? Metabolic & Homeostasis Models
Used in models investigating metabolic rate, body temperature, and sympathetic nervous system activity.

???? Reconstitution & Storage

• Diluent: Sterile or Bacteriostatic Water (USP Grade)

• Reconstitution Volume:

  • 5mg → 1mL

  • 10mg → 2mL

• Reconstituted Storage: 2–8°C (Stable for 30 days)

• Do not freeze reconstituted solution

• Avoid repeated freeze-thaw cycles

???? Included with Purchase

• 1 vial of Protirelin (TRH) peptide – 5mg or 10mg

• HPLC-verified Certificate of Analysis

• Tamper-proof, pharma-grade U.S. packaging

• Optional cold-chain shipping

???? U.S. Legal Disclaimer

Protirelin is not approved by the FDA for human or veterinary use. This product is intended for laboratory research use only in the United States. It is not a drug, food, or supplement and must be handled by qualified professionals in authorized research facilities.