Icatibant Peptide – 5mg & 10mg Vials

Product Name: Icatibant
Synonyms: HOE-140, Bradykinin Receptor Antagonist, Icatibant Acetate
CAS Number: 30308-48-4
Molecular Formula: C59H89N19O13
Molecular Weight: 1305.48 g/mol
Form: Lyophilized White Powder
Purity: ≥98% (HPLC Verified)
Available Sizes: 5mg and 10mg vials
Storage (Lyophilized): –20°C, dry and dark
Storage (Reconstituted): 2–8°C (stable for 30 days)
Use: For laboratory research only in the United States

Overview

Icatibant is a synthetic deca-peptide bradykinin B2 receptor antagonist extensively studied in inflammation, vascular permeability, and pain signal modulation research. It is best known for blocking the activity of bradykinin, a key mediator in acute inflammatory responses.

At ChemDope, we supply research-grade Icatibant in 5mg and 10mg formats with ≥98% purity, synthesized under cGMP conditions in the U.S.

✅ Key Features

• Synthetic peptide with potent bradykinin B2 receptor blocking action

• High-purity peptide (≥98%)

• Available in 5mg and 10mg sterile vials

• Ideal for use in neuroinflammation, vasodilation, and edema research

• Manufactured in the USA in FDA-registered facilities

• Batch-specific Certificate of Analysis (CoA) provided

• U.S. cold-shipping available

🔬 Mechanism of Action

Icatibant is a competitive antagonist of the bradykinin B2 receptor, preventing bradykinin from binding and activating its pro-inflammatory signaling cascade. This blockade helps researchers evaluate its effects on:

• Vascular permeability

• Edema formation

• Smooth muscle contraction

• Pain receptor sensitivity (nociception)

🔬 Research Applications

🔥 Inflammation & Edema Research

🧬 Vascular Studies
Explores how bradykinin antagonism affects blood vessel permeability and vasodilation.

💉 Pain Pathway Modeling
Investigates bradykinin-induced hyperalgesia and receptor signaling in chronic pain models.

🧠 Neuroinflammation
Explored in the context of nerve injury, migraine, and neurogenic inflammation models.

🧪 Reconstitution & Storage Guidelines

• Diluent: Sterile or Bacteriostatic Water

• Suggested Reconstitution:

  • 5mg vial → 1mL = 5mg/mL

  • 10mg vial → 2mL = 5mg/mL

• Storage (Reconstituted): 2–8°C (up to 30 days)

• Avoid multiple freeze-thaw cycles

📦 What’s Included

• 1 vial of Icatibant Peptide (5mg or 10mg)

• HPLC-verified Certificate of Analysis

• Sealed, tamper-proof vial with lot number tracking

• Optional cold-pack shipping across the U.S.

🚫 U.S. Legal Disclaimer

Icatibant is not FDA-approved for human or veterinary use. It is intended exclusively for laboratory research in the United States. This product is not a drug, dietary supplement, or therapeutic agent, and must be handled only by qualified professionals in certified research environments.