Cagrilintide

Cagrilintide (also known as AM833) is a long-acting amylin analogue peptide engineered to mimic the biological effects of native amylin, a hormone co-secreted with insulin. It is being studied extensively for its roles in appetite suppression, gastric emptying delay, glucose regulation, and body weight control.

In research models, Cagrilintide shows strong synergistic effects when combined with GLP-1 agonists like Semaglutide or Tirzepatide, making it a key candidate in combination therapy for obesity and type 2 diabetes studies.

⚙️ Key Features

• ✅ Available in both 5mg and 10mg vials

• ✅ High-purity ≥98%, HPLC tested

• ✅ Synthetic amylin receptor agonist

• ✅ Ideal for use in appetite, metabolic, and combination research

• ✅ Manufactured in GMP-compliant facilities

• ✅ Supplied with batch-specific CoA

📚 Mechanism of Action

Cagrilintide mimics the action of amylin, a neuroendocrine hormone that:

• Slows gastric emptying, promoting early satiety

• Decreases postprandial glucagon secretion

• Acts on the area postrema and hypothalamus to reduce appetite

• Complements insulin and GLP-1 receptor activity in metabolic pathways

Its extended half-life makes it highly effective in once-weekly dosing models.

🔬 Research Applications

🍽️ Appetite Suppression Research
Studied for its impact on caloric intake, satiety signaling, and hypothalamic activity.

⚖️ Obesity & Weight Management
Used to evaluate body weight reduction, fat mass loss, and synergy with GLP-1 agonists.

🧪 Glucose Metabolism & Diabetes Studies
Applied in postprandial glucose control, insulin resistance, and hormonal interaction research.

🧬 Combination Therapy Models
Explored in dual or triple therapy research with Semaglutide, Tirzepatide, and other incretin mimetics.

🧪 Reconstitution & Storage Instructions

• Recommended Diluent: Bacteriostatic Water (BAC)

• Volume: 1–2mL per vial

• Storage (Lyophilized): -20°C, sealed, light-protected

• Storage (Reconstituted): 2–8°C, use within 15–30 days

• Avoid repeated freeze/thaw cycles

📦 What You Receive

• 1 vial of Cagrilintide (5mg or 10mg)

• Certificate of Analysis (CoA)

• Tamper-evident packaging

• Cold-chain shipping available

🚫 Disclaimer

Cagrilintide is intended for laboratory research use only. Not for human or veterinary consumption. Only qualified institutions or researchers may handle this peptide.