KPV Peptide

KPV (Lys-Pro-Valine) is a naturally occurring tripeptide fragment derived from alpha-melanocyte-stimulating hormone (α-MSH). Recognized for its powerful anti-inflammatory properties, It is a small, bioactive peptide that inhibits pro-inflammatory cytokines, making it a highly researched compound in immunology, inflammatory bowel disease (IBD), gut health, skin conditions, and wound healing studies.

KPV 10mg vials are supplied in a lyophilized (freeze-dried) powder form, ideal for researchers needing stable, long-lasting material for preclinical and in vitro studies. Our peptide is manufactured at ≥98% purity, ensuring consistent performance and reproducibility in your laboratory work.

Key Product Specifications:

• Peptide Name: KPV (Lysine–Proline–Valine)

• Form: Lyophilized powder

• Purity: ≥98% (HPLC Verified)

• Net Content: 10mg/5mg per vial

• Molecular Formula: C17H32N6O4

• Molecular Weight: ~384.5 g/mol

• Sequence: Lys-Pro-Val

• Storage: Store dry at -20°C; use reconstituted solution within 30 days at 2–8°C

• Solubility: Soluble in sterile water or peptide-grade solvents

Mechanism of Action:

KPV exerts its biological effects by inhibiting NF-κB activation, reducing the expression of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6. It also works independently of melanocortin receptors, allowing it to reduce inflammation without affecting melanogenesis.

KPV has been shown to suppress inflammation in various epithelial tissues including the intestinal lining, skin, and mucosal surfaces, making it a valuable model peptide in autoimmune, allergic, and gut barrier studies.

Research Applications of KPV Peptide:

1. Inflammatory Bowel Disease (IBD) & Gut Health

KPV is widely studied for its therapeutic potential in managing inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. It helps maintain gut barrier integrity and reduces intestinal inflammation without suppressing immune surveillance.

2. Skin Inflammation & Wound Healing

Research shows KPV promotes wound healing and suppresses skin inflammation by limiting the action of pro-inflammatory mediators. It’s useful in psoriasis, eczema, and atopic dermatitis models.

3. Autoimmune & Allergy Research

Due to its cytokine-suppressing abilities, KPV is being evaluated in autoimmune disorders and allergy studies. It limits mast cell degranulation and histamine release, making it relevant for allergic inflammation models.

4. Immune Modulation & Mucosal Immunity

KPV supports immune tolerance in mucosal surfaces and is being explored for its role in oral immunotherapy and gut-brain axis modulation.

Why Choose KPV for Your Research?

• Small, potent tripeptide: Easy to work with and highly stable

• Non-toxic and well-tolerated in preclinical models

• Highly targeted action with minimal off-target effects

• No pigmentation effect (unlike full-length α-MSH)

• Stable in plasma and ideal for localized inflammation models

How to Use KPV Peptide in Research:

Reconstitution Instructions:
Reconstitute the lyophilized KPV powder using sterile bacteriostatic water or peptide-grade solvent. Gently swirl until fully dissolved. Avoid vigorous shaking or vortexing.

Storage Guidelines:

• Store lyophilized vials at -20°C

• Use reconstituted solutions within 30 days at 2–8°C

• Protect from light and avoid freeze-thaw cycles

Safety Information & Legal Disclaimer:

For Laboratory Research Use Only. Not for human consumption.
This product is not intended to diagnose, treat, cure, or prevent any disease. Use only in qualified research laboratories by trained professionals. Not for medical, veterinary, or clinical applications.

Who Should Use KPV Peptide?

Ideal for researchers involved in:

• Inflammatory signaling pathway studies

• Mucosal immunity and gut permeability research

• Dermatological and skin regeneration modeling

• Peptide-based anti-inflammatory therapy development

• Wound healing and tissue repair experiments

Benefits of High-Purity KPV Peptide:

• ≥98% purity confirmed by HPLC

• Sterile-sealed, tamper-evident vials for quality control

• Reliable batch-to-batch consistency

• Free from fillers or additives

• Suitable for in vitro and in vivo testing models