Protirelin (TRH Peptide) – 5mg & 10mg

Product Name: Protirelin
Synonyms: TRH, Thyrotropin-Releasing Hormone, Thyroliberin, TRH-Tyr
CAS Number: 24305-27-9
Molecular Formula: C16H22N6O4
Molecular Weight: ~362.39 g/mol
Form: Lyophilized White Powder
Purity: ≥98% (HPLC Verified)
Sizes Available: 5mg and 10mg vials
Storage (Lyophilized): –20°C, protected from light and moisture
Storage (Reconstituted): 2–8°C for up to 30 days
Use: For laboratory research only in the United States

Product Overview

Protirelin (TRH) is a tripeptide hormone known as Thyrotropin-Releasing Hormone, a key regulator in the hypothalamic-pituitary-thyroid (HPT) axis. It stimulates the anterior pituitary to secrete thyroid-stimulating hormone (TSH) and prolactin in mammalian models.

At ChemDope.com, we provide research-grade Protirelin in 5mg and 10mg vials, manufactured in FDA-registered U.S. facilities under cGMP conditions. Each vial includes a Certificate of Analysis (CoA) and is tested for ≥98% purity by HPLC.

✅ Key Features

• High-purity TRH peptide (≥98% by HPLC)

• 5mg & 10mg sterile lyophilized vials

• Manufactured in the USA under strict cGMP conditions

• Targets thyroid regulation, neuroendocrine activity & CNS stimulation

• CoA included with batch traceability

• Fast U.S. shipping with cold-pack option available

🔬 Mechanism of Action

Protirelin (TRH) acts primarily on the anterior pituitary gland, binding to specific TRH receptors to stimulate:

• TSH (Thyroid Stimulating Hormone) release

• Prolactin secretion

• Central nervous system effects such as increased alertness and sympathetic tone

Due to its role in thyroid hormone regulation, Protirelin is a powerful tool for research into metabolism, neurobiology, endocrine feedback loops, and neurotransmitter modulation.

🧪 Research Applications

🧠 Endocrine System Research
Used in models to study thyroid hormone regulation, HPT axis feedback, and pituitary signaling.

🔥 Neuroendocrinology Studies
Explores TRH’s role in arousal, mood, and neuropeptide release.

💉 Prolactin Regulation Research
Applied in studies examining dopamine-prolactin interaction and hypothalamic function.

🧬 Metabolic & Homeostasis Models
Used in models investigating metabolic rate, body temperature, and sympathetic nervous system activity.

🧪 Reconstitution & Storage

• Diluent: Sterile or Bacteriostatic Water (USP Grade)

• Reconstitution Volume:

  • 5mg → 1mL

  • 10mg → 2mL

• Reconstituted Storage: 2–8°C (Stable for 30 days)

• Do not freeze reconstituted solution

• Avoid repeated freeze-thaw cycles

📦 Included with Purchase

• 1 vial of Protirelin (TRH) peptide – 5mg or 10mg

• HPLC-verified Certificate of Analysis

• Tamper-proof, pharma-grade U.S. packaging

• Optional cold-chain shipping

🚫 U.S. Legal Disclaimer

Protirelin is not approved by the FDA for human or veterinary use. This product is intended for laboratory research use only in the United States. It is not a drug, food, or supplement and must be handled by qualified professionals in authorized research facilities.