Angiotensin II Peptide – 5mg & 10mg Vials | Research Use Only

Product Name: Angiotensin II
Synonyms: Ang II, Hypertensin, Angiotensin Peptide
CAS Number: 4474-91-3
Molecular Formula: C50H71N13O12
Molecular Weight: ~1046.2 Da
Sequence: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
Form: Lyophilized Powder
Available Sizes: 5mg and 10mg vials
Purity: ≥98% (HPLC Verified)
Storage (Lyophilized): -20°C, protected from moisture/light
Storage (Reconstituted): 2–8°C for up to 30 days
Use: For Laboratory Research Only

🔬 Product Overview

Angiotensin II is a short octapeptide hormone involved in blood pressure regulation and fluid balance, functioning as a core part of the Renin-Angiotensin-Aldosterone System (RAAS). It is a potent vasoconstrictor, studied widely in cardiovascular, renal, and hypertensive disease models.

ChemDope’s Angiotensin II is produced using GMP-grade synthesis, offered in 5mg and 10mg formats for flexible dosing in in vivo and in vitro applications.

✅ Key Features

• Lyophilized Angiotensin II in 5mg and 10mg formats

• ≥98% purity, HPLC-tested and GMP-synthesized

• Mimics endogenous Ang II biological activity

• Strong binding to AT1 and AT2 receptors

• Ready for cardiovascular, renal, and hypertensive modeling

• Batch-specific Certificate of Analysis (CoA) included

📚 Mechanism of Action

Angiotensin II binds to angiotensin type 1 (AT1) and type 2 (AT2) receptors, initiating vasoconstriction, aldosterone release, and sympathetic nervous system activation.

Key effects in models include:

• Increased vascular resistance and blood pressure

• Stimulated aldosterone and ADH secretion

• Altered electrolyte and fluid retention

• Enhanced cell proliferation, inflammation, and fibrosis in cardiac/renal tissues

🔬 Research Applications

🫀 Hypertension & Cardiovascular Models
Used in studies of vasoconstriction, atherosclerosis, and cardiac hypertrophy.

🧪 Kidney & Renal Function Studies
Explores glomerular filtration, nephron injury, and renal inflammation.

🧬 Inflammation & Fibrosis Research
Assessed in models evaluating tissue damage and repair pathways.

🧠 Neurohormonal Regulation Studies
Relevant to brain RAAS signaling, ADH response, and behavioral physiology.

🧪 Reconstitution & Handling

• Diluent: Sterile Water or Bacteriostatic Water (BAC)

• Reconstitution Volume:

  • 5mg → add 1mL = 5mg/mL

  • 10mg → add 2mL = 5mg/mL

• Storage (Lyophilized): -20°C

• Storage (Reconstituted): 2–8°C (stable for up to 30 days)

• Avoid multiple freeze-thaw cycles

📦 What You’ll Receive

• 1 vial of Angiotensin II (choose 5mg or 10mg)

• Certificate of Analysis (CoA)

• Sealed, research-grade packaging

• Optional cold-chain shipping available

🚫 Disclaimer

Angiotensin II is strictly for research use only. Not for human use, medical treatment, or diagnostic procedures. Use in certified lab environments only.