TB-500 (Thymosin Beta-4)

Product Name: TB-500 (Thymosin Beta-4 Acetate)
Synonyms: Thymosin Beta-4, Tβ4, TB500
CAS Number: 77591-33-4
Molecular Formula: C212H350N56O78S
Molecular Weight: 4963.5 g/mol
Purity: ≥98% (HPLC Verified)
Form: Lyophilized White Powder
Storage (Lyophilized): -20°C, protected from light
Storage (Reconstituted): 2–8°C; stable for 15–30 days
Use: For Laboratory Research Only – Not for Human or Veterinary Use

🔬 Product Overview

TB-500, also known as Thymosin Beta-4, is a synthetic version of a naturally occurring peptide found in nearly all human and animal cells. It is primarily used in scientific research for its tissue-regenerating, wound-healing, and anti-inflammatory properties. TB-500 is a potent actin-binding peptide, which allows it to play a central role in cell migration, angiogenesis, and tissue regeneration.

In preclinical models, TB-500 has shown the ability to promote faster recovery from injury, reduce inflammation, and stimulate collagen deposition and new blood vessel formation.

⚙️ Key Features

• ✅ ≥98% purity (HPLC & MS verified)

• ✅ Synthetic peptide identical to human Thymosin Beta-4

• ✅ Promotes healing, tissue regeneration, and reduced inflammation

• ✅ Manufactured in GMP and ISO-certified labs

• ✅ Ideal for musculoskeletal and cardiac recovery studies

📚 Mechanism of Action

TB-500 is a synthetic analog of Thymosin Beta-4, a naturally occurring 43-amino acid peptide. Its primary mechanism involves binding to globular (G) actin, a component of the cytoskeleton, thereby promoting cell migration, differentiation, and tissue remodeling.

Its biological effects include:

• Promotion of angiogenesis (new blood vessel formation)

• Reduced fibrosis and inflammation

• Accelerated wound closure

• Increased keratinocyte and endothelial cell migration

🔬 Primary Research Applications

🩺 Wound Healing & Recovery Models
Used in skin, corneal, and tendon injury research to study accelerated healing and reduced scarring.

💪 Muscle & Tendon Regeneration
Evaluated in studies involving soft tissue injuries, especially in ligaments, tendons, and skeletal muscle fibers.

❤️ Cardiovascular Repair Research
Tested for its ability to reduce damage following myocardial injury and promote angiogenesis in heart tissue.

🔥 Anti-Inflammatory & Fibrosis Control
Models involving inflammatory cytokine suppression, scar tissue reduction, and collagen modulation.

🧬 Hair Growth & Dermatological Studies
Used in experiments on hair follicle stimulation, skin hydration, and cell turnover.

🧪 Reconstitution & Handling Instructions

• Solvent: Bacteriostatic Water (BAC)

• Storage (Lyophilized): -20°C in a light-protected container

• Storage (Reconstituted): 2–8°C (stable for 15–30 days)

• Avoid Freezing Reconstituted Vial

• Light Sensitivity: Store in a dark vial or foil wrap

📦 What’s Included

• HPLC-tested TB-500 peptide (2mg / 5mg vial)

• Certificate of Analysis (CoA)

• Safety Data Sheet (SDS)

• Secure packaging with batch number and expiry

• Optional cold-chain shipping for sensitive orders

🚫 Disclaimer

TB-500 is sold strictly for laboratory research use only. It is not approved for human or veterinary use, clinical studies, or consumption. All buyers must be qualified researchers or licensed institutions.