Retatrutide 

Retatrutide (LY3437943) is a cutting-edge triple receptor agonist that simultaneously activates GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors. It is among the most advanced compounds under investigation for extreme weight loss, metabolic syndrome, glucose control, and energy expenditure.

This triagonist is designed to combine the effects of incretin signaling with enhanced lipid oxidation, showing superior efficacy in preclinical obesity and diabetes research models.

⚙️ Key Features

• ✅ Potent GIP, GLP-1, and glucagon receptor agonist

• ✅ High-purity lyophilized peptide: ≥98% HPLC tested

• ✅ Available in 5mg and 10mg formats

• ✅ GMP-compliant manufacturing with full CoA

• ✅ Advanced peptide for metabolism & weight loss studies

• ✅ Long-acting profile supports once-weekly dosing in models

📚 Mechanism of Action

Retatrutide’s triple-receptor mechanism makes it unique among metabolic peptides:

• GIP Receptor Activation: Enhances insulin secretion & improves beta-cell function

• GLP-1 Receptor Activation: Regulates blood sugar, reduces appetite, delays gastric emptying

• Glucagon Receptor Activation: Boosts lipid oxidation & energy expenditure

This synergistic action leads to greater fat mass reduction, improved glycemic control, and enhanced energy metabolism in research settings.

🔬 Primary Research Applications

⚖️ Obesity & Weight Loss Research
Preclinical studies show significant body weight reduction and appetite suppression.

🩺 Type 2 Diabetes Models
Evaluated for its impact on glucose levels, insulin sensitivity, and HbA1c markers.

🔥 Energy Expenditure Studies
Used to explore basal metabolic rate increases and fat oxidation pathways.

🧬 Metabolic Syndrome & Inflammation
Applied in studies on lipid profiles, inflammation markers, and cardiometabolic health.

🧪 Reconstitution & Storage Instructions

• Diluent: Bacteriostatic Water (BAC)

• Recommended Reconstitution Volume: 1–2mL per vial

• Storage (Lyophilized): -20°C in a dry, light-protected container

• Storage (Reconstituted): 2–8°C for up to 30 days

• Do not freeze after reconstitution

• Use under sterile conditions

📦 Package Includes

• 1 Vial of Retatrutide (5mg or 10mg)

• Batch-specific Certificate of Analysis (CoA)

• GMP manufacturing info

• Secure, tamper-evident packaging

• Cold-chain shipping option available

🚫 Disclaimer

Retatrutide is sold for laboratory research purposes only. Not for human or veterinary use. Use by qualified personnel in a controlled research environment only.