Buy Adipotide Peptide 5mg & 10mg

Adipotide, also known as FTPp, is a synthetic fat-targeting peptide designed to trigger apoptosis (programmed cell death) in white adipose tissue (WAT) vasculature. Extensively studied in preclinical models for its fat-reducing and anti-obesity effects, Adipotide offers a revolutionary approach to metabolic and obesity research.

Available in 5mg and 10mg lyophilized vials, this high-purity peptide is for research use only, intended for laboratory testing related to fat metabolism, weight loss, and vascular targeting strategies.

Chemical & Physical Properties:

• Product Name: Adipotide (FTPp)

• Synonyms: Prohibitin-Targeting Peptide, FTPp

• Form: Lyophilized powder

• Purity: ≥98% (HPLC Verified)

• Available Sizes: 5mg / 10mg per vial

• Molecular Formula: C60H91N17O13S

• Molecular Weight: ~1289.5 g/mol

• Sequence: CKGGRAKDC-GG-D(KLAKLAK)2

• Storage Conditions: Store at -20°C dry. After reconstitution, refrigerate at 2–8°C and use within 30 days.

• Solubility: Soluble in sterile water or acetic acid + PBS buffer

Mechanism of Action:

Adipotide is a dual-function peptide consisting of two components:

1. Targeting Domain (CKGGRAKDC):
   Binds selectively to prohibitin, a mitochondrial membrane protein overexpressed in the endothelial cells of white adipose tissue vasculature.

2. Effector Domain (D(KLAKLAK)₂):
   This cytotoxic sequence disrupts mitochondrial membranes, leading to apoptosis of targeted endothelial cells and subsequent fat cell degradation due to nutrient supply disruption.

This leads to a reduction in fat mass and improved metabolic biomarkers like insulin sensitivity, making Adipotide a subject of great interest in obesity, diabetes, and fat metabolism studies.

Research Applications of Adipotide:

1. Obesity and Weight Loss Research

Adipotide has demonstrated the ability to cause significant fat loss in animal models (nonhuman primates, mice, rats) by selectively inducing fat cell apoptosis through blood vessel shutdown in WAT, without affecting muscle or other tissues.

2. Insulin Sensitivity & Diabetes Models

Fat loss via Adipotide administration correlates with enhanced insulin sensitivity, suggesting potential in type 2 diabetes and metabolic syndrome research. It allows scientists to explore non-traditional metabolic pathways that bypass the central nervous system or appetite regulation.

3. Vascular-Targeted Therapy Exploration

Adipotide represents a model for vascular-targeted therapeutics. Its two-domain design is useful in studying vascular disruption techniques, delivery systems, and tissue-specific cytotoxicity models.

4. Mitochondrial Membrane Disruption Studies

The D(KLAKLAK)₂ portion is useful in mitochondrial biology research, particularly in modeling apoptosis pathways, peptide internalization, and cellular energy disruption.

Advantages of Adipotide in Research:

• Selectively targets white fat vasculature

• Does not affect brown adipose tissue (BAT)

• Operates independently of hunger/appetite regulation

• Demonstrated significant fat reduction in primate studies

• Potential model for peptide-drug conjugates and targeted delivery

• Useful in researching non-hormonal, fat-reducing agents

Reconstitution & Storage Guidelines:

• Reconstitute using sterile bacteriostatic water or peptide-grade acetic acid (0.6%) followed by dilution in PBS

• Gently swirl the vial to dissolve—do not shake vigorously

• Store lyophilized powder at -20°C

• Once reconstituted, keep at 2–8°C and use within 30 days

• Avoid repeated freeze-thaw cycles

Important Safety & Handling Disclaimer:

For Research Use Only. Not for human or veterinary use.
Adipotide is not intended for therapeutic, diagnostic, or clinical applications. Use by qualified researchers only in a controlled laboratory setting. Always follow local, national, and institutional guidelines for handling research chemicals.